That’s kind of like saying can I take sumatriptan with Ibuprofen. Yes, you can. Ibuprofen and sumatriptan are both used to treat depression, but they aren’t exactly the same. Ibuprofen is a non-selective NSAID (non-selective inhibitor of cyclooxygenase type I). It does not affect the serotonin (5-HT) system.
Ibuprofen is also used to treat migraine headaches. It does have a higher risk for a severe allergic reaction. It even can lead to a severe anaphylactic reaction in some people. Its also used to treat pain.
Sumatriptan is another NSAID. It is a selective inhibitor of the 5-HT2A receptor which is important in the regulation of the hypothalamus. It is used to treat migraine headaches and to reduce nausea and vomiting. It is one of the few drugs that can reduce the nausea associated with motion sickness.
Sumatriptan is one of those drugs that you really can take with anything and still not make yourself sick. Because a huge number of people are allergic to NSAIDs, there are many people who take it with other drugs, like alcohol and antacids, but still don’t get sick. It even works with some prescription medications, like aspirin and ibuprofen. This is another reason why we love Sumatriptan.